Immununodermatology is the study and treatment of the Immune-Mediated Skin Diseases such as psoriasis. Systemic Lupus Erythematous (SLE), Bullous Pemphigoid (BP) and Pemphigus Vulgaris (PV) are some type of autoimmune diseases, in which our body immune system mistakenly acts against our own healthy cells or tissue or parts of the body. Systemic Lupus Erythematous (SLE) also known as lupus. In this case, most commonly face tissue will affect. The root cause is not entirely clear, it is believed to involve some hormones, environmental and genetic factors. There is no permanent cure for SLE, but corticosteroids, immunosuppressant, hydroxychloroquine and methotrexate will help to reduce the effects. Bullous Pemphigoid is a chronic autoimmune disorder, which will form the blisters (Bullae) at the space between the epidermis and dermis layers of the skin. It comes under the Type II Hypersensitivity. Immunofluorescence study will help to diagnose this disease. Pemphigus Vulgaris is a rare chronic blistering (Oral blisters) skin disease. It also comes under Type II Hypersensitivity.